buy Lidocaine Hydrochloride at factory price from supplier CAS NO.73-78-9
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- LIDOCAINE HCL
- buy Lidocaine Hydrochloride
- Lidocaine Hydrochloride at factory price
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- ProName: buy Lidocaine Hydrochloride at factory...
- CasNo: 73-78-9
- Molecular Formula: C14H23ClN2O
- Appearance: powder
- Application: Cosmetics / Pharmaceuticals
- ProductionCapacity: Metric Ton/Day
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- LimitNum: 0 Metric Ton
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Lidocaine hydrochloride(Odorless, slightly bitter and numb. Very soluble in water, ethanol and organic solvents, but insoluble in ether. The aqueous solution does not decompose under the conditions of acid and alkali, and repeated autoclaving rarely deteriorates.) is highly penetrating, diffuse and fast-acting. Its anesthetic performance is twice that of procaine, and its toxicity is similar.
Lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious excitatory and inhibitory biphasic effects on the central nervous system and can have no pioneering excitement. When blood concentration is low, analgesia and lethargy, pain threshold increase; with increasing dose It causes an increase in action or toxicity and has anticonvulsant effects in sub-poisoning plasma concentrations.
Anesthesia can occur 5 minutes after administration, and the anesthesia can last for 1 to 1.5 hours, which is 50% longer than procaine. After absorption, it can inhibit the central nervous system, inhibit ventricular autonomy, shorten refractory period, and can be used to control ventricular tachycardia, treat ventricular premature beats, ventricular tachycardia, and ventricular fibrillation and other symptoms of arrhythmia. It is effective for heart disease or arrhythmia caused by cardiac glycosides and is not effective for supraventricular tachycardia. This product has a fast effect, short duration, and is ineffective in oral administration. It is often administered intravenously.
Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity, and excitability.
Lidocaine hydrochloride is a moderate-effect amide local anesthetic. Used as a local anesthetic and antiarrhythmic drug. Mainly used:
(1) Infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia for thoracoscopic or abdominal surgery) and nerve block.
(2) treatment of acute myocardial infarction (AMI) after ventricular premature beats and ventricular tachycardia, and digitalis poisoning, cardiac surgery, cardiac catheter-induced ventricular arrhythmia, but usually not effective for supraventricular arrhythmia.